The cytokine LIF and its downstream transcription factor Stat3 play crucial roles in induction and maintenance of pluripotency. Stat3 has been reported to localise to different organelles, exerting different effects on the cell. We reported that Stat3 controls both nuclear transcription and mitochondrial activity in pluripotent cells. We are currently studying whether and how the two organelles communicate and we are also interested in the evolutionary conservation of such molecular activities.
To know more: Carbognin et al., 2016 doi ; Peron et al., 2020 doi .
This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 716910).