Pluripotent Stem Cell Biology
Pluripotent stem cells (PSCs) have the ability to give rise to all cell types found in the adult body, making them the perfect tool for regenerative medicine as well as an intellectually fascinating cell type, given their lack of any developmental restriction.
PSCs were initially derived from early mammalian embryos, but are currently obtained by reprogramming adult cells. Our laboratory studies the biology of PSCs, how they are maintained, how they differentiate, how they are generated via reprogramming and how to use them for disease modeling. To do so we look at the interplay between transcription factors, metabolism and epigenetics, combining molecular, cellular and computational biology.