Martello Lab

Pluripotent Stem Cell Biology

Publications

2021

PsiNorm: a scalable normalization for single-cell RNA-seq data
Matteo Borella, Graziano Martello, Davide Risso, Chiara Romualdi
Bioinformatics 2021 Sep 9:btab641. doi
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation
Margherita Peron, Alberto Dinarello, Giacomo Meneghetti, Laura Martorano, Riccardo M Betto, Nicola Facchinello, Annachiara Tesoriere, Natascia Tiso, Graziano Martello, Francesco Argenton
Development 2021 Sep 1;148(17):dev199477. doi
Metabolic control of DNA methylation in naive pluripotent cells
Riccardo M. Betto, Linda Diamante, Valentina Perrera, Matteo Audano, Stefania Rapelli, Andrea Lauria, Danny Incarnato, Mattia Arboit, Silvia Pedretti, Giovanni Rigoni, Vincent Guerineau, David Touboul, Giuliano Giuseppe Stirparo, Tim Lohoff, Thorsten Boroviak, Paolo Grumati, Maria E. Soriano, Jennifer Nichols, Nico Mitro, Salvatore Oliviero & Graziano Martello
Nature Genetics 2021. doi

2020

Mitochondrial STAT3 regulates proliferation of tissue stem cells
Peron M, Meneghetti G, Dinarello A, Martorano L, Betto RM, Facchinello N, Tiso N, Martello G, Argenton F
bioRxiv 2020.07.17.208264. doi
Embryonic stem cells commit to differentiation by symmetric divisions following a variable lag period
Strawbridge SE, Blanchard GB, Smith A, Kugler H, Martello G
bioRxiv 2020.06.17.157578. doi
Allelic expression analysis of Imprinted and X-linked genes from bulk and single-cell transcriptomes
Martini P, Sales G, Perrera V, Diamante L, Romualdi C, Martello G
bioRxiv 2020.05.20.105841. doi
Esrrb Conveys Naïve Pluripotent Cells Through The Formative Transcriptional Program
Carbognin E, Carlini V, Panariello F, Perrera V, Malucelli C, Cesana M, Mutarelli M, Carissimo A, Hackett JA, Cacchiarelli D, Martello G.
Available at SSRN
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
Zorzan I, Pellegrini M, Arboit M, Incarnato D, Maldotti M, Forcato M, Tagliazucchi GM, Carbognin E, Montagner M, Oliviero S, Martello G.
Nature Communications 2020 May 12;11(1):2364. doi

2019

How Does Reprogramming to Pluripotency Affect Genomic Imprinting?
Perrera V, Martello G.
Frontiers in Cell and Developmental Biology 2019 May 9;7:76. doi
Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics
Giulitti S, Pellegrini M, Zorzan I, Martini P, Gagliano O, Mutarelli M, Ziller MJ, Cacchiarelli D, Romualdi C, Elvassore N, Martello G.
Nature Cell Biology 2019 Feb;21(2):275-286. doi
A common molecular logic determines embryonic stem cell self-renewal and reprogramming
Dunn SJ, Li MA, Carbognin E, Smith A, Martello G.
EMBO Journal 2019 Jan 3;38(1):e100003. doi

2016

A Method to Identify and Analyze Biological Programs through Automated Reasoning
Yordanov B, Dunn SJ, Kugler H, Smith A, Martello G, Emmott S.
Nature Systems Biology and Applications 2016 Jul 7;2:16010. doi
Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency
Carbognin E, Betto RM, Soriano ME, Smith AG, Martello G.
EMBO Journal 2016 Mar 15;35(6):618-34. doi
The nature of embryonic stem cells
Martello G, Smith A.
Annual Review of Cell and Developmental Biology 2014;30:647-75. doi

2014

Defining an essential transcription factor program for naïve pluripotency
Dunn SJ, Martello G, Yordanov B, Emmott S, Smith AG.
Science 2014 Jun 6;344(6188):1156-1160. doi

2013

Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor
Martello G, Bertone P, Smith A.
EMBO Journal 2013 Oct 2;32(19):2561-74. doi

2012

Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal
Martello G, Sugimoto T, Diamanti E, Joshi A, Hannah R, Ohtsuka S, Göttgens B, Niwa H, Smith A.
Cell Stem Cell 2012 Oct 5;11(4):491-504. doi

Publications since 2016 are supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 716910).